Issue 25 - Cannabis vs. Cancer, Schizophrenia, and More: Is This Plant the Ultimate Medical Multitasker?

BudMed Bulletin for 27/02/2025

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Could cannabis hold the key to fighting ovarian cancer?

Cannabinoids like CBD and CBG stick tightly to a key cancer protein (HER2) and block its activity. CBD binds the strongest, even better than a common cancer drug, while CBG is a close second. CBG is the best at stopping the protein’s signals, with CBD not far behind. Both hook onto critical spots on the protein, messing up its function. In tests, CBD and CBG slowed the growth of HER2-positive ovarian cancer cells, matching traditional drugs. Source

What is the Link Between Cannabis Use Disorder and schizophrenia?

Spoiler - genetics. "He also noted that both cannabis use disorder and schizophrenia share chromosomal loci, suggesting a deeper genetic link that warrants further investigation."... "As a result, he sees potential for cannabis-based treatments in a wide range of psychiatric and neurological disorders, including sleep disorders, feeding and eating disorders, sexual dysfunction, and elimination disorders." Source

Cannabis & HIV: Could Cannabis Be Rewiring Your Gut and Immunity?

Gut protection: Cannabis use seems to boost the immune system in your gut, making it better at fighting off threats. Calmer immune system: It also lowers overall immune activity, so your body isn’t overreacting or getting too inflamed. Unique gut bugs: Cannabis changes the mix of bacteria in your gut (the microbiome), giving it a distinct makeup compared to non users. HIV connection: There’s some early evidence that cannabis might affect how HIV hides in the body (called reservoirs). Source

Vaping or Smoking? Cannabis versus Tobacco. Shocking Breath Test Reveals How They Stack Up for Your Lungs!

Cannabis users: People using cannabis had inflammation chemical levels closer to non users, often lower than tobacco users. Their overall breath profile was also more like non users than tobacco users. Burning vs. vaping: When people smoked tobacco or cannabis (burning it), their breath had way more metabolites compared to non users. But those using e-cigarettes or vape pens (for nicotine or THC) had much lower levels of these metabolites. What it means: Smoking cigarettes seems to mess with lung chemistry more than cannabis or vaping. Vaping (whether nicotine or cannabis) has a smaller impact on the lungs’ chemical makeup compared to traditional smoking. In short, this study shows that regular cigarettes cause more lung changes than cannabis or e-devices, with vaping looking less harsh on the breath profile. Source

Cannabis Compound Zaps Colon Cancer Cells via CB2 Receptor – Mutation-Proof!

"Our results demonstrate that CBD induces apoptosis and halts proliferation, migration, and invasion of CRC cell lines in a concentration-dependent manner." Source

Recreational cannabis laws spark a drop in opioid fills for insured adults—study reveals a surprising shift in pain med habits!

Cannabis increasingly substitutes traditional pain meds as recreational access grows Small shift after legalization; bigger impact once dispensaries open Opioid fills drop, non-opioid pain meds rise slightly Patients may swap opioids for cannabis, non-opioid meds, or both Fewer opioid fills could cut new users, addiction, and harm. Source

Over 50 and in pain? Medical cannabis could be your game-changer!

Safe, effective treatment for older patients with pain-related conditions Improved pain, sleep, and quality of life Reduced need for other medications Cost-effective compared to traditional drugs No serious adverse events reported. Source

"Irish neurologists prescribing cannabis as treatment for MS and other medical conditions"

"Neurologists in Ireland have revealed they are prescribing cannabis-based medicines for symptoms such as pain and spasticity in their patients." Source

"Purified cannabidiol leads to improvement of severe treatment-resistant behavioral symptoms in children with autism spectrum disorder"

"Conclusion: Our results suggest that treatment with purified CBD is effective and safe and could benefit patients with severe ASD by improving some of the core symptoms, including repetitive behaviors and social interaction, as well as associated comorbidities. The families considered the quality of life to have improved." Source

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Disclaimer: The content provided in this newsletter by BudMed Bulletin is for informational and educational purposes only. It is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or another qualified health provider with any questions you may have regarding a medical condition or the use of medical cannabis.