Issue 32 - Can Cannabis Revolutionize Asthma, Addiction, and Cancer Care?

BudMed Bulletin for 17/04/2025

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Could CBD Fight Oral Cancer? Study Shows It Damages Cancer Cell DNA & Kills Tumors

CBD slows down oral cancer growth by damaging cancer cell DNA. Higher doses and longer exposure to CBD lead to more cancer cell death. Doses of CBD at or above 25 micromolar greatly reduce cancer cell survival. CBD might be a new treatment option for oral squamous cell carcinoma due to its ability to kill cancer cells. Source

Can Cannabis Boost Cancer Treatment? Studies Say It Could Supercharge Chemo & Fight Tumors!

Back in 1975, animal studies first showed that THC and other plant-based compounds (phytocannabinoids) could fight cancer. In the early 1990s, scientists learned about the body's endocannabinoid system, and many studies confirmed these anti-cancer effects across different types of tumors. Research shows cannabinoids can target key aspects of tumor growth, making them a hot topic for new cancer treatments. Early studies suggest combining cannabinoids with chemotherapy could make chemo work better and help when tumors resist treatment. Source

Could CBD Be a Game-Changer for Tough-to-Control Epilepsy?

CBD addition to pharmacoresistant epilepsy treatment is beneficial in most cases. Higher dose (20 mg/kg/day) showed superior seizure control. Lower dose (10 mg/kg/day) also demonstrated significant efficacy. Lower dose is a viable option for treatment and guideline inclusion. Source

Could Cannabis Be an Asthma Game-Changer? Study Shows THC Inhaler Matches Ventolin in Opening Airways Fast

Lung function results: Both THC and salbutamol improved breathing significantly. Speed of relief: Salbutamol worked faster, but after one hour, both THC and salbutamol were equally good at opening airways. Side effects: Neither drug caused heart issues or mood changes. THC levels: No THC was found in the blood 15 minutes after inhaling, based on a lab test. How THC works: It helps asthma differently than typical asthma drugs (like salbutamol), suggesting THC or a similar compound could be a helpful add-on treatment for some asthma patients. Source

"From Cravings to Calm: Cannabis Sparks a New Era in Addiction Recovery"

Participant Benefits: Cannabis helped manage pain, anxiety, depression, and sleep issues, which often challenge recovery. Reduced cravings for opioids and other substances reported. Improved mental health and sleep quality noted. Stigma Challenges: Staff skepticism and stigma around cannabis use persist, highlighting a need for better education. Source

New Study Shows How Two Death Triggers Join Forces to Fight Cancer Treatment Resistance!

Cancer connection: Cancer cells resisting apoptosis (cell death) cause tumors to grow and resist treatment. Parthanatos (A unique way cells die, not like the usual cleanup process) can kill cancer cells (e.g., in brain cancer or leukemia) when triggered by certain drugs or compounds. Treatment ideas: Drugs that start parthanatos might work when apoptosis fails. Combining drugs that trigger both apoptosis and parthanatos can kill cancer cells better. Stressing cancer cells with specific chemicals can push both death pathways to work. New findings: Using parthanatos with apoptosis, plus boosting immunity or targeting bone-related cancer spread, could improve treatments for tough cancers. Source

Daily Cannabis Use Cuts Fatty Liver Risk by 36% in HIV-HCV Patients"

Daily cannabis use linked to less fatty liver: People who use cannabis every day seem to have a lower chance of getting steatosis (fat buildup in the liver). Study adjusted for other factors: The researchers made sure this wasn’t just because of things like body weight, risky drinking, or certain HIV meds (lamivudine/zidovudine). Even after accounting for those, the cannabis effect held up. Numbers show a small but real link: The stats (adjusted odds ratio of 0.64) suggest daily cannabis users are about 36% less likely to have steatosis, with a confidence range of 42% to 1% less likely. The p-value (0.046) means it’s just significant enough to not be random chance. Might protect HIV-HCV patients: For people with both HIV and hepatitis C, daily cannabis could act like a shield against fatty liver. Source

Can Cannabis Calm Autism? Shocking Study Reveals CBD Extracts Boost Social Skills and Slash Disruptive Behavior in Kids!

CBD helped kids be more social (worked well, with consistent results across studies). CBD reduced disruptive behavior (worked a bit, with consistent results). CBD lowered anxiety (worked a bit, but results varied between studies). Source

Liver Cancer’s New Foe? CBD Flips the Switch on Tumor Growth

CBD slows down liver cancer growth: When researchers used CBD (a compound from cannabis) on hepatocellular carcinoma (HCC) cells, it made these cancer cells less able to grow and spread, both in lab dishes (in vitro) and in living animals (in vivo). CBD tweaks key cell controls: CBD lowered the levels of a protein called GRP55 in the cancer cells, while boosting another protein called TP53. It also stopped a process called MAPK signaling, which cancer cells use to grow fast. Flipping the switch back: If researchers forced the cancer cells to make more GRP55 again or removed TP53, the cancer cells regained their ability to grow and spread, even with CBD around. This shows GRP55 and TP53 are big players in CBD’s effects. How it works: CBD basically turns down GRP55, which then ramps up TP53 and blocks MAPK signaling. Together, this puts the brakes on the cancer cells’ growth and their ability to spread to other parts of the body. Source

"Cannabis Is A Better Sleep Aid Than OTC And Rx Pills, Study Finds"

"When compared to other medical sleep aids, nearly 70% of respondents reported that medical cannabis is more effective at improving sleep quality than other prescription medications, and almost 70% noted fewer side effects. Compared to over-the-counter sleep aids, 91.2% of those surveyed considered medical cannabis to be the more effective option, while only 1.7% disagreed." Source

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Disclaimer: The content provided in this newsletter by BudMed Bulletin is for informational and educational purposes only. It is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or another qualified health provider with any questions you may have regarding a medical condition or the use of medical cannabis.