Issue 35 - Cannabis & CBD Breakthroughs: Slashing Cancer Risk, Revolutionizing Lung Cancer Treatment, and Transforming Epilepsy Care

BudMed Bulletin for 08/05/2025

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Could cannabis lower your risk of cancer?

Cannabis and kidney cancer: People who used cannabis in the past had a lower risk of developing kidney cancer (about 39% less likely). This was statistically significant. Cannabis and prostate cancer: Past cannabis use was linked to a lower risk of prostate cancer (about 18% less likely), also statistically significant. Cannabis and bladder cancer (women only): Women who used cannabis before had a lower risk of bladder cancer (about 57% less likely), but this wasn’t seen in men. Cannabis and kidney cancer (women only): Women with past cannabis use had a lower risk of kidney cancer (about 58% less likely), but this wasn’t observed in men. Cannabis and testicular cancer: No link was found between cannabis use and the risk of testicular cancer. Causal link for kidney cancer: A method called Mendelian randomization suggested that cannabis use might directly lower the risk of kidney cancer. Source

Could CBD Revolutionize Lung Cancer Treatment?

What’s being studied? They tested cannabidiol (CBD), a compound from cannabis, with etoposide, a chemotherapy drug, to see if they work better together against non-small cell lung cancer (NSCLC). Key finding: Among various chemo drugs tested, etoposide worked best with CBD, significantly reducing NSCLC cancer cell survival. How does it work? The combo boosts genes that cause cancer cells to die through a process called autophagy (self-destruction). It also lowers the activity of genes that help cancer grow. What’s the mechanism? The treatment shuts down a pathway (PI3K–AKT–mTOR) that helps cancer cells grow and survive. This effect depends on a protein called p53, which is often involved in cancer. Surprising discovery: CBD’s anticancer effects don’t rely on typical cannabis-related receptors or channels, suggesting it works in a unique way. Why is this important? Combining CBD with etoposide could be a new, effective treatment for NSCLC, especially when standard treatments don’t work, by killing cancer cells and stopping tumor growth. Who could benefit? This approach may help patients with NSCLC, particularly those with tumors where p53 is functional. Source

Could CBD & Immune Cells Be a Game-Changer for Lung Cancer? New Study Uncovers Powerful Tumor-Killing Combo!

CBD and CIK Team-Up: When CBD (a compound from cannabis) was combined with CIK immune cells, they worked together to: Kill more lung cancer cells. Produce more of a substance (IFN-g) that helps the immune system fight cancer. CBD Boosts Immune Cells: CBD increased specific groups of CIK cells, which means it: Activated these immune cells early on. Helped them become "memory" cells that are better at fighting cancer long-term. CBD and Calcium in Immune Cells: CBD caused more calcium to flow into CIK cells through the TRPV2 channel, which: Increased a protein (p-ERK) that makes CIK cells more effective at killing cancer. CBD Damages Cancer Cells: In lung cancer cells, CBD: Caused DNA damage by making it harder for cancer cells to survive. Reduced the cancer cells' ability to move and spread. Source

Could CBD Be a Game-Changer for Kids with Tough-to-Treat Epilepsy?

Study Shows 49% of Patients Had Seizures Cut by 25% or Less, 20% Saw 76-99% Drop, and 5% Nearly Seizure-Free! Source

Could a Cannabis Compound Be the Key to Fighting Obesity & Diabetes?

How THCV works: Blocks CB1 receptors to reduce appetite. Activates CB2 receptors to improve blood sugar control and energy use. Preclinical research (lab and animal studies) shows THCV: Improves insulin sensitivity and sugar uptake in cells. Restores insulin function in tissues. Reduces fat buildup in fat cells and liver cells. Boosts mitochondrial activity (cell energy production). Decreases appetite and prevents fatty liver disease. Helps maintain metabolic balance. Source

Can Medical Cannabis Help ADHD? UK Study Reveals Surprising Results!

Quality of Life Improvement: Patients reported better overall health and well-being (measured by a tool called EQ-5D-5L) at 1, 3, and 6 months after treatment. These improvements were statistically significant (p < 0.050, meaning there's a low chance the results happened by accident). Anxiety and Sleep Improvement: Patients showed reduced anxiety (measured by GAD-7) and better sleep quality (measured by SQS) at 1, 3, 6, and 12 months. These improvements were also statistically significant (p < 0.010, meaning even more confidence in the results). Source

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Disclaimer: The content provided in this newsletter by BudMed Bulletin is for informational and educational purposes only. It is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or another qualified health provider with any questions you may have regarding a medical condition or the use of medical cannabis.