Issue 37 - Cannabis Breakthroughs Unveiled: From Hidden Receptors in Breast Cancer to Revolutionary Treatments for Alzheimer’s, Pain, and Diabetes!

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Shocking Discovery: Cannabinoid Receptors Hide in Breast Cancer Cells' Nucleoli!

CB2 receptor (CB2R): This receptor in cells is linked to how aggressive breast cancer can be, especially in tumor growth. Study focus: Researchers looked at CB2R in two triple-negative breast cancer (TNBC) cell lines (one early-stage, one metastatic) and compared them to a normal breast cell line. CB2R location: Found on cell surfaces but mostly inside cells. About 40 times higher in TNBC cells than in normal cells. Mostly in the nucleoli (a part of the cell's nucleus) of cancer cells. CB2R in cell cycle: Lower in cells that are dividing (mitotic) compared to resting (interphase) cells.

Effect of HU-308 (a drug): Moves CB2R out of the nucleoli to other parts of the cell (nucleus and cytoplasm). Reduces cancer cell movement (migration) and growth (proliferation). Potential use: CB2R's presence in nucleoli could be a marker to detect TNBC early. Source

Could CBD Revolutionize Alzheimer’s Treatment?

In cells with Aβ, CBD triggers processes called autophagy (cell cleanup) and apoptosis (cell death) through specific pathways (LC3B and Caspase-3). Aβ (beta-amyloid) is a protein fragment that can build up in the brain, forming sticky clumps called plaques. Source

Shocking Relief! 93% of chronic pain patients swear by medical cannabis, with 77.5% using it daily & minimal side effects. Is this the future of pain relief?

“Conclusions: Long-term MC use is a stable and well-tolerated option for managing chronic musculoskeletal pain, with high patient-reported efficacy and minimal cognitive impact. These findings support its role in pain management..." Source

Could cannabis compounds revolutionize diabetes treatment?

Study findings: Tested five cannabis compounds on pancreatic β-cells exposed to high sugar and fat levels (mimicking T2DM conditions). All five compounds reduced cell death by lowering levels of a harmful protein (TXNIP). THC and the three minor compounds (THCV, CBC, CBG) also protected β-cells from functional damage caused by high sugar and fat. Source

Could your DNA unlock the secret to better medical marijuana results?

Progress in research: Researchers have found specific genetic differences that influence how individuals respond to cannabis, which is a big step forward. Benefits of this research: Understanding these genetic factors can: Improve how well cannabis treatment works for each person. Reduce unwanted side effects. Personalized medicine: By using pharmacogenomics, doctors can tailor cannabis therapy to each patient’s unique genetic makeup for better, safer results. Source

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Disclaimer: The content provided in this newsletter by BudMed Bulletin is for informational and educational purposes only. It is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or another qualified health provider with any questions you may have regarding a medical condition or the use of medical cannabis.