Issue 41 - Could CBD and CBN Kill Cancer, Soothe Endometriosis, and Supercharge Stem Cell Therapy?

BudMed Bulletin for 06/19/2025

Spread the word about the latest in medical cannabis! Pass on these breakthroughs to empower someone’s health journey.

Could CBD be a game-changer for colorectal cancer?

How CBD kills cancer cells: Apoptosis (programmed cell death): CBD triggers cells to self-destruct by reducing proteins that prevent cell death and increasing signs of cell death (seen in Annexin-V and TUNEL tests). Paraptosis (another type of cell death): CBD causes stress in a cell part called the endoplasmic reticulum and increases harmful oxygen molecules, leading to cell death. This is linked to higher levels of proteins ATF4 and CHOP. Autophagy (cell cleanup process): CBD boosts proteins (Atg7, phospho-Beclin-1, LC3) that help cells break down and recycle their own parts, which can lead to cell death. Source

Could a cannabis compound stop cancer in its tracks?

Slows cancer growth: CBN slows down the growth of these cancer cells. Affects receptors: CBN changes the levels of certain cell receptors (like GPR18, CB2, and GPR55) that are part of how cells communicate. Blocks cell signals: In brain and liver cancer cells, CBN reduces activity of a pathway called ERK1/2, which helps cells grow. In breast cancer cells, it reduces activity of another pathway called AKT, also linked to cell growth. Triggers cell death: CBN may cause cancer cells to die by lowering levels of proteins (p21 and p27) that protect cells. Halts cell cycle: CBN stops cancer cells from dividing by pausing their growth cycle at specific stages (G1 or S-phase) and reducing proteins (CDK1, CDK2, cyclin E1) needed for cell division. Source

Endometriosis Sufferers Turn to Cannabis for Relief: 99% Swear By It

Why do they use cannabis? Main reason: Current pain treatments don’t work well enough (68.6%). Other reasons: Side effects from regular medicines are too harsh (56.3%), and they worry about getting hooked on prescription drugs (43.9%). Do they keep using it? Yes, 99% plan to continue using cannabis because it helps their symptoms. Would they recommend it? 90% would suggest cannabis to a friend or family member with endometriosis. How does cannabis compare to regular medicines? People think cannabis works better and has fewer side effects than prescription drugs. Source

Could CBD Revolutionize Stem Cell Therapy?

CBD helps the stem cells grow and turn into fat cells, even without the usual chemicals used to trigger this change. The cells showed signs of becoming fat cells, like forming fat droplets, producing fat-related proteins, and rearranging their internal structure. CBD also influenced genes related to bone cell formation, suggesting it might affect other cell types too. Why does this matter? Controlling how these stem cells turn into fat cells could make them more useful for medical treatments, like repairing tissues or treating diseases. Source

Can Cannabis Ease Nerve Pain? Study Shows 79% of Trials Report Significant Relief!

Out of 927 studies, 14 high-quality ones (randomized controlled trials) were chosen. 13 of these 14 studies (79%) showed that cannabis medicines significantly reduced nerve pain. Other benefits included better sleep, reduced sensory issues (like tingling), and improved quality of life. Source

Breakthrough: CBD supercharges colon cancer treatment by boosting zinc-regulating proteins, slashing tumor growth!

Key findings: CBD changed the activity of genes involved in DNA repair and cell division. Genes called metallothioneins (MT) were much more active after CBD treatment. In colon cancer tissues, MT genes are less active than in healthy tissues, suggesting low MT activity may help cancer grow. CBD's effect on MT genes: Tests (qPCR) showed CBD specifically boosts MT gene activity, unlike other cannabis compounds or crude cannabis extract. Synergy discovered: Combining CBD with MT gene activation or zinc treatment made CBD better at fighting cancer cells. Source

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Disclaimer: The content provided in this newsletter by BudMed Bulletin is for informational and educational purposes only. It is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or another qualified health provider with any questions you may have regarding a medical condition or the use of medical cannabis.