Issue 49 - Cannabis Unveiled: Breakthroughs in Cancer, Glaucoma, Brain Aging, and Skin Health Transform Medicine!

BudMed Bulletin for 14/08/2025

Spread the word about the latest in medical cannabis! Pass on these breakthroughs to empower someone’s health journey.

Video: "Cannabis and Cancer: Breakthroughs and Personal Stories" – Explore how medical cannabis is transforming cancer treatment, backed by research and survivor testimonials.

Shocking Breast Cancer Breakthrough: Brief CB2 Receptor Activation Locks Cancer Cells into a Less Aggressive State, Boosting Tamoxifen Response!

CB2R activation helps control cancer cells: Activating cannabinoid receptor 2 (CB2R) with certain compounds pushes breast cancer cells to become more stable and less aggressive. Short-term, low-dose treatment works: Using natural or synthetic CB2R-activating compounds for a short time changes cancer cells from a dangerous (basal) type to a less harmful (luminal) type. Reduced cancer abilities: This treatment makes cancer cells less likely to grow uncontrollably, spread, or start new tumors. Resists reversal: The changes stick even under conditions (like growing with other cells, immune system pressure, or physical stress) that usually make cancer cells revert to a more dangerous state. Source

CBD slashes tumor spread by blocking MALAT1 & key pathways, boosting chemo’s power without harming healthy cells. Could this be a game-changer?

What is PDAC? PDAC is a very aggressive type of pancreatic cancer that spreads quickly and doesn’t respond well to standard chemotherapy. Why is it hard to treat? The cancer cells change through a process called epithelial-mesenchymal transition (EMT), which makes them more likely to spread (metastasize). Certain signals in the body (like chemokines) help the cancer cells move and invade other tissues. What did the study find about CBD? CBD, a non-psychoactive compound from cannabis, shows promise in fighting this cancer. It reduces the activity of proteins (CXCR4/CXCR7 and MMP-2/9) that help cancer cells spread, making it harder for PDAC cells to move or invade other parts of the body. CBD reverses the EMT process, turning cancer cells back to a less aggressive state by boosting “good” (epithelial) markers and lowering “bad” (mesenchymal) markers. How does CBD work? It blocks a molecule called MALAT1, which normally promotes cancer spread by turning on EMT. MALAT1 also activates a pathway (PI3K/Akt/mTOR) that helps cancer grow and spread, but CBD shuts this pathway down. What happens when CBD is combined with chemotherapy? When used with gemcitabine (a common chemo drug), CBD works even better to reduce MALAT1, EMT, and the cancer-promoting pathway. This combination doesn’t harm healthy cells, suggesting it’s a safe and effective option. Why is this important?CBD could help stop PDAC from spreading and make chemotherapy work better, offering a new way to improve treatment for this tough cancer. Source

Could a cannabis compound save your sight? New study shows dronabinol boosts optic nerve blood flow by up to 12% in glaucoma patients

The 10 mg dose of dronabinol significantly improved blood flow to the optic nerve (by about 10–12%) for up to 4 hours compared to the placebo. It also increased blood vessel density in part of the eye by about 6.7% (compared to the 5 mg dose). Dronabinol didn’t change eye pressure or blood pressure. This is important because some patients still lose vision even when their IOP is lowered, suggesting other factors (like poor blood flow) may also harm the optic nerve. This could make it a helpful add-on treatment for glaucoma, especially for patients with poor eye blood flow. Source

Cannabis Could Turn Back the Clock on Brain Aging!

Cannabis users showed "younger" brain patterns: People who used cannabis had brain connection patterns that looked more like those of younger people, unlike non-users. Cannabis users did better on cognitive tests: Those who used cannabis performed better in tasks testing memory, attention, and other thinking skills. Cannabis might slow brain aging: The study suggests cannabis could help protect the brain from aging-related decline, possibly by supporting brain flexibility or compensating for age-related losses. Cannabinoids may play a role: Chemicals in cannabis (and similar ones naturally in the body) might help reduce brain degeneration, offering a possible explanation for these effects. Source

Could cannabis be the key to soothing itchy, inflamed skin?

What is atopic dermatitis (AD)? A long-term skin condition causing intense itching and inflammation. Researchers tested extracts from a hybrid Cannabis sativa plant (HCIE) to see if it can reduce skin inflammation and symptoms of AD in human skin cells. HCIE contains 8 types of cannabinoids, with CBDA and CBD making up about 28% of the extract. HCIE reduced inflammation-causing chemicals (MDC, RANTES, TARC) in a dose-dependent way (more extract = stronger effect). It blocked pathways (MAPK, NF-κB, NLRP3, JAK1/STAT6) that trigger inflammation in skin cells. It increased proteins (filaggrin, involucrin) that help keep skin hydrated and healthy. Source

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Disclaimer: The content provided in this newsletter by BudMed Bulletin is for informational and educational purposes only. It is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or another qualified health provider with any questions you may have regarding a medical condition or the use of medical cannabis.