BudMed Bulletin for 24/10/24

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Cannabis and Epilepsy: Revolutionising Seizure Control with Remarkable Therapeutic Success

Introduction

Cannabis and Epilepsy. In this edition, we focus on the promising role of cannabis in epilepsy management. Recent studies reveal cannabis’s potential in reducing seizure frequency and enhancing life for those with treatment-resistant epilepsy. We'll explore the science behind cannabis’s effectiveness, its use in paediatric cases, and its impact on various epileptic syndromes. Dive into this issue for a concise look at how cannabis is reshaping epilepsy treatment paradigms.

Definition. Epilepsy is a central nervous system (neurological) disorder in which brain activity becomes abnormal, causing seizures or periods of unusual behaviour, sensations, and sometimes loss of awareness.

Symptoms. Epilepsy manifests through various seizure types, each with distinct symptoms. Common signs include temporary confusion, staring spells, uncontrollable jerking movements, and loss of consciousness or awareness. Focal seizures might cause localised motor, sensory, or psychological symptoms like muscle twitching or strange sensations, whereas complex partial seizures often involve altered consciousness with repetitive actions. Generalised seizures range from absence seizures, characterised by brief lapses in awareness, to tonic-clonic seizures, which involve body stiffening followed by jerking movements.

Prevalence. The prevalence of epilepsy, based on a systematic review and meta-analysis of international studies, indicates that the point prevalence of active epilepsy is approximately 6.38 per 1,000 persons, while the lifetime prevalence is about 7.60 per 1,000 persons.

The Science Behind Cannabis and Epilepsy

Revolutionising Epilepsy Treatment: A Deep Dive into Cutting-Edge Therapies. "Cannabidiol (CBD), derived from cannabis herbs, has garnered attention for its anticonvulsant properties, offering a potential adjunctive therapy for refractory seizures. " Source

Cannabidiol (CBD) in Epilepsy: A Multi-Target Approach. “So, in essence, this research indicates that CBD might help control epilepsy by directly interacting with and stabilising a key protein (GluR2) that's genetically linked to the condition, leading to beneficial changes in how this protein functions.” Source

Clinical Evidence and Trials

Cannabidiol is showing groundbreaking results in treating drug-resistant epilepsy in kids & young adults. "CBD leading to a reduction in seizure frequency ranging from 50% to complete seizure freedom." Source

The Use of Compounds Derived from Cannabis sativa in the Treatment of Epilepsy. "Drawing from surveys, patient studies, and clinical trials, it highlights the potential of cannabis in alleviating symptoms, slowing disease progression, and improving overall quality of life for patients." Source

New research highlights CBD's role in significantly reducing seizures in kids with Dravet Syndrome. "Notably, CBD demonstrated substantial reductions in seizure frequency, with some patients achieving seizure freedom. The findings emphasised the consistency of CBD’s efficacy across different patient subgroups." Source

Patient Quality of Life Improvements

Unlocking New Hope in Epilepsy Treatment. "Along with its anti seizure effects, CBD demonstrated clinical beneficial effects in patients’ quality of life, sleep and numerous adaptive behaviours" Source

Patient Stories

Meet Edie: A Story of Hope. Edie's life changed dramatically when traditional treatments for him epilepsy fell short. Now, he’s finding relief through cannabis-based therapy. His journey sheds light on a green alternative for paediatric epilepsy. Video Link

Meet Millie: Triumph Over Epilepsy! Millie's life was once defined by relentless seizures, but now, she's thriving thanks to cannabis therapy. Her story adds to the growing evidence of cannabis's potential in paediatric epilepsy. Video Link

Meet Billy Caldwell: Life Saved by Medical Cannabis. Billy's severe epilepsy once threatened his life daily until medical cannabis changed everything. His mother's relentless fight led to legal changes in the UK. Now, Billy thrives, seizure-free. Video Link

Meet Alfie Dingley: A Beacon of Hope in Epilepsy Treatment! Alfie's severe epilepsy once dictated his life with countless seizures until his mother, Hannah Deacon, fought for change. Now, with medical cannabis, Alfie's life has transformed, showcasing the potential of cannabis in paediatric epilepsy care. Video Link

Conclusion

As we conclude this issue of the Medical Cannabis Newsletter, it's clear that the journey of cannabis in the realm of epilepsy treatment is just beginning. The evidence presented underscores cannabis’s potential as a powerful ally in the fight against epilepsy, particularly in cases where traditional treatments fall short. The stories of reduced seizure frequencies, improved quality of life, and the hope of seizure freedom are not just scientific outcomes but beacons of hope for many.

While the path from research to widespread clinical adoption is often slow, the progress made thus far invites optimism. The rescheduling recommendations and the growing acceptance of medical cannabis reflect a shifting tide in both medical practice and public policy.

We stand at the brink of what could be a new era in epilepsy management, where cannabis compounds like CBD might no longer be the alternative but a standard in therapeutic strategies. As we continue to learn, advocate, and innovate, let's keep pushing for more research, better access, and comprehensive understanding of cannabis's full potential in treating not just epilepsy but a spectrum of medical conditions.

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Disclaimer: The content provided in this newsletter by BudMed Bulletin is for informational and educational purposes only. It is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or another qualified health provider with any questions you may have regarding a medical condition or the use of medical cannabis.