BudMed Bulletin for 12 Feb 2026

In this issue:

  • CBD destroys aggressive breast cancer cells!

  • CBD fights depression, anxiety, epilepsy, neuro degeneration & more!

  • CBD derivative a game-changing multi-target Alzheimer's drug?

  • ER+ breast cancer: Cannabis slams the brakes on tumor growth !

  • Cannabis users' brains look YOUNGER!

  • Cannabis users showed LESS brain aging/decline!

  • Lifetime cannabis use linked to BIGGER brain volumes!

A PubMed study reports: CBD destroys aggressive breast cancer cells!

  • CBD worked by:Boosting harmful oxygen molecules (ROS) inside the cells.

  • It caused unusual cell death (not normal suicide/apoptosis):

  • Paraptosis — slow, bloated cell death

  • Ferroptosis — iron-triggered toxic fat damage

Biochemical Pharmacology study reports: CBD fights depression, anxiety, epilepsy, neuro degeneration & more!

  • CBD fights:

  • Depression

  • Anxiety

  • Protecting brain cells (neuroprotective)

  • Reducing psychosis symptoms (antipsychotic)

  • Stopping nausea/vomiting (antiemetic)

  • Easing certain types of pain (anti-allodynic)

  • Controlling seizures (anti-epileptic)Slowing brain degeneration

  • Helping treat addictions

A PubMed study reports: CBD derivative a game-changing multi-target Alzheimer's drug?

  • One compound, called G-12, stood out as the best:

  • It very strongly reduces inflammation

  • It powerfully protects brain cells from dying.

  • By calming inflammation and oxidative damage, G-12 reduces amyloid-beta buildup and protects brain cells overall.T

  • his multi-target approach — hitting several key problems of Alzheimer's at once — appears very effective.

A PubMed study reveals: ER+ breast cancer: Cannabis slams the brakes on tumor growth !

  • AEA and THC mainly killed the cancer cells by triggering apoptosis (natural programmed cell death, like the cell "choosing" to die in an orderly way).

  • CBD worked differently: it first triggered autophagy (the cell starts "eating" its own damaged parts), which then led to apoptosis and cell death.

  • All three reduced levels of aromatase (lowering estrogen production) and ERα (the main estrogen receptor that promotes cancer growth when activated).

  • AEA and CBD were especially strong at directly blocking aromatase activity and also increased levels of ERβ (a different estrogen receptor that often opposes cancer growth and is considered protective)

A Research Square study reports: Cannabis users' brains look YOUNGER!

  • People who used cannabis showed better scores on various thinking tests (multiple areas of cognition / mental performance).

  • The brain changes linked to cannabis and the better thinking abilities appeared together across many different brain systems.

  • Cannabis users' brains showed connection patterns more like those seen in younger people, plus stronger cognitive (thinking) skills.

A PubMed study indicates: Cannabis users showed LESS brain aging/decline!

  • Main finding: Men who had ever used cannabis actually showed less drop in their cognitive (thinking) abilities over the decades compared to men who never used it.

  • Among the cannabis users, things like starting at a young age or using it frequently did not lead to worse long-term cognitive decline.

  • Overall conclusion: In this large group of men tracked for over 40 years, cannabis use did not cause harmful long-term effects on age-related brain aging or cognitive decline.

A PubMed study reports: Lifetime cannabis use linked to BIGGER brain volumes!

  • Key findings on the brain:

  • People who had used cannabis more over their lifetime tended to have larger brain volumes in specific regions that have lots of cannabinoid receptors (the parts of the brain that respond to cannabis compounds).

  • These regions included the caudate and putamen (involved in movement and habits), hippocampus (important for memory), and amygdala (involved in emotions).

  • Key findings on thinking and memory:

  • More lifetime cannabis use was linked to better scores on tests for learning new things, quick thinking/processing speed, and short-term memory.

  • Even people who only used cannabis during their teenage years (then stopped) showed larger brain areas in those regions and better thinking performance compared to people who never used it.

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Disclaimer: The content provided in this newsletter by BudMed Bulletin is for informational and educational purposes only. It is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or another qualified health provider with any questions you may have regarding a medical condition or the use of medical cannabis.

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